How your body works

Follow a cup of coffee, a slice of bread or a tablet into your cells, and see who paid for every study behind each fact.

Start with something familiar

Each everyday thing below opens a short route through the molecules it meets.

A statin tablet

One enzyme in the liver slows, and the liver takes more LDL cholesterol out of the blood.

An egg

Cholesterol from food meets the cholesterol the liver makes, and people balance the two differently.

The map of your metabolism

The central chemistry of a human cell on one chart. Point at a pathway to name it; select it to open its chapter.

Central pathways of human metabolismABCDEFGHIJKL12345678CytosolMitochondrionEndoplasmic reticulumHexokinase, glucokinaseHKPhosphoglucose isomerasePhosphofructokinase-1PFK-1Aldolase ATriose phosphate isomeraseGAPDH, phosphoglycerate kinase (NADH, ATP)Phosphoglycerate mutase, enolasePyruvate kinase (ATP)PKLactate dehydrogenaseLDHGlycolysisGlucose-6-phosphataseG6PaseFructose-1,6-bisphosphataseFBPasePyruvate carboxylase and PEP carboxykinase, via oxaloacetatePC, PEPCKGluconeogenesisVia glucose-1-phosphate: glycogen phosphorylase for breakdown, glycogen synthase via UDP-glucose for synthesisGlucose-6-phosphate dehydrogenase and two further steps (2 NADPH)G6PDRibose-5-phosphate isomerasePRPP synthetase and several stepsPentose phosphate pathwayKetohexokinase (fructokinase)KHKAldolase B; glyceraldehyde enters as glyceraldehyde-3-P via triokinaseAldolase BPyruvate dehydrogenase complex (thiamine pyrophosphate)PDHCitrate synthase, with oxaloacetateAconitaseIsocitrate dehydrogenase (NADH, CO₂)α-Ketoglutarate dehydrogenase (NADH, CO₂)Succinyl-CoA synthetase (GTP or ATP)Succinate dehydrogenase, complex II (FADH₂)FumaraseMalate dehydrogenase (NADH)Citrate synthaseCitric acid cycleNADH dehydrogenase (complex I) reduces ubiquinone; succinate dehydrogenase (complex II) also reduces ubiquinoneMetforminUbiquinol to cytochrome bc1 complex (complex III)Complex III reduces cytochrome cCytochrome c oxidase (complex IV) reduces O₂ to H₂OComplexes I, III and IV pump protons; the proton gradient drives ATP synthaseOxidative phosphorylationCarnitine palmitoyltransferase 1 and 2 (carnitine shuttle)CPT1Beta-oxidation spiral (FADH₂, NADH)Beta-oxidationCitrate export and ATP-citrate lyaseACLYAcetyl-CoA carboxylase 1 (ATP, biotin)ACCFatty acid synthase (NADPH)FASNAcyl-CoA synthetase, acyltransferases, with glycerol-3-PFatty acid synthesisGlycerol kinase (liver)Glycerol-3-phosphate dehydrogenaseThiolase, HMG-CoA synthase 2, HMG-CoA lyase (liver)HMGCS2KetogenesisAcetyl-CoA acetyltransferase 2HMG-CoA synthase 1HMG-CoA reductase (2 NADPH), rate-limitingHMGCRStatinsMevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase (3 ATP)Isopentenyl-PP isomerase, farnesyl-PP synthaseFDPSPolyprenyl synthesis toward coenzyme Q10cis-PrenyltransferaseFarnesyltransferase, geranylgeranyl transferasesSqualene synthase (NADPH)FDFT1Squalene epoxidase, lanosterol synthaseSQLESeveral steps (Kandutsch-Russell branch; the Bloch branch ends with desmosterol and DHCR24)7-Dehydrocholesterol reductaseDHCR7Cholesterol 7α-hydroxylase and further steps (liver)CYP7A1Cholesterol side-chain cleavage enzyme in mitochondria of adrenal and gonadal cellsCYP11A1UVB photolysis in skin, then thermal isomerisationUVBCholesterol synthesisCarbamoyl phosphate synthetase 1 (2 ATP, activated by N-acetylglutamate)CPS1Ornithine transcarbamylase, with ornithineOTCArgininosuccinate synthetase, with aspartate (ATP)ASS1Argininosuccinate lyase, releases fumarateASLArginase 1ARG1Arginase 1 regenerates ornithineOrnithine import (ORNT1) to ornithine transcarbamylaseUrea cycleTransamination (aminotransferases, pyridoxal phosphate); glutamate dehydrogenaseAlanine aminotransferaseALTPHGDH, PSAT1, PSPH (three steps)Amino acidsDihydrofolate reductase, two reductions (NADPH)DHFRSerine hydroxymethyltransferase: serine to glycineSHMTMethylenetetrahydrofolate reductaseMTHFRMethionine synthase (vitamin B12) transfers the methyl group to homocysteineMethionine synthase (vitamin B12)MTR, B12Methionine adenosyltransferase (ATP)MATMethyltransferases donate the methyl groupS-adenosylhomocysteine hydrolaseAHCYSerine supplies the carbon of 5,10-methylene-THFFolate and methionine cyclesAlcohol dehydrogenase (ADH1B), CYP2E1ADHAldehyde dehydrogenase 2 (ALDH2)ALDH2GlycogenGlucoseGlucose-6-PFructose-6-PFructose-1,6-P₂Glyceraldehyde-3-P3-PhosphoglyceratePhosphoenolpyruvatePyruvateLactateRibulose-5-PRibose-5-PNucleotidesFructoseFructose-1-PDHAPGlycerolGlycerol-3-PFatty acyl-CoAAcetyl-CoAMalonyl-CoAPalmitateTriacylglycerolsAcetoacetyl-CoAHMG-CoAMevalonateIsopentenyl-PPFarnesyl-PPUbiquinoneDolicholPrenylated proteinsSqualeneLanosterol7-DehydrocholesterolCholesterolBile acidsSteroid hormonesVitamin D₃Fatty acyl-CoAAcetyl-CoAKetone bodiesOxaloacetateCitrateIsocitrateα-KetoglutarateSuccinyl-CoASuccinateFumarateMalateIQIIIcIVATP synthaseGlutamateNH₄⁺ + HCO₃⁻Carbamoyl-PCitrullineArgininosuccinateArginineOrnithineUreaEthanolAcetaldehydeAcetateAlanineSerineFolic acidTHF5,10-CH₂-THF5-CH₃-THFHomocysteineMethionineSAMSAH

Point at a pathway to see its name. Double arrows mark reversible steps; dotted arrows mark the steps that run backwards when the liver makes glucose.

  • Sugars
  • Fats and cholesterol
  • Energy
  • Amino acids
  • Folate and B12
  • Alcohol
  • Where a medicine acts

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Method

How every source on this site is classed by who paid for it.